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Bone metastasis proceeds with the macrophages and DTCs via VCAM-1 bone marrow and areas adjacent to the bone matrix.

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A direct interaction between lung macrophages and DTCs via VCAM-1 evokes tumor cell pro-survival signaling and promotes lung metastasis. VCAM-1 also mediated bone metastasis in other mouse and human breast cancer cell lines. Choose a collection Unable to load your collection due to an error Please try again. Tumor cells entering the lung parenchyma are immediately surrounded by macrophages, probably as a result of an innate immune response. X-ray crystallography defines the three-dimensional structure of the N-terminal two-domain fragment that participates in ligand binding.